简单描述:The Dutch mutation (E22Q) of amyloid β-peptide aggregates more readily than the wild-type peptide and the resulting fibrils show increased neurotoxicity. The mutant peptide E22Q induced apoptosis of cerebral endothelial cells at a concentration of 25 μ-;m, whereas WT Aβ 1-40 and the Italian mutant E22K (H-6698) showed no effect.
英文名:(Gln²²)–Amyloid β–Protein (1–40)
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